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Patients with rectal cancer who sustained clinical complete response after neoadjuvant chemoradiotherapy for 1 year with a watch-and-wait strategy seemed to have low risk for local regrowth and distant metastases during the next 2 years, researchers reported.
In the study of 793 patients with clinical complete response being managed by watch-and-wait strategy at 47 clinics in 15 countries, the probability of remaining free of local regrowth for 2 additional years after 1 year of clinical complete response was 88.1%, according to Rodrigo Perez, PhD, of Hospital Alemao Oswaldo Cruz in Sao Paulo, Brazil, and colleagues.
This increased to 97.3% if clinical complete response was sustained for 3 years, and to 98.6% if sustained for 5 years, they stated in the