Editorial Article: Organoid-based 3D model of human glioblastoma: Recreating brain tumors in a dish
Discover how a brain organoid core facility is applying its glioblastoma model towards developing patient mini-brains
08 Apr 2021
Glioblastoma, the deadliest of primary brain tumors in adults, has a median survival of only about 15 months, with less than 6% of patients surviving past the five-year mark. The urgent need to fully understand the cancer biology of glioblastoma is thwarted by the lack of a suitable disease model that mimics the cerebral microenvironment.
Dr. Richa Singhania, Director of the Starr Foundation Glionoid Translational Core at Weill Cornell Medicine
In recent times, cerebral organoids, the self-assembling three-dimensional cellular models derived from stem cells, have opened up the possibility of replicating the brain’s milieu to closely examine and study glioblastomas.