Scientists reprogram a common bacterium to make designer sugar-based drug
Envisioning an animal-free drug supply, scientists have -; for the first time -; reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals. Published today in
Nature Communications, the researchers modified
E. coli to produce chondroitin sulfate, a drug best known as a dietary supplement to treat arthritis that is currently sourced from cow trachea.
Genetically engineered
E. coli is used to make a long list of medicinal proteins, but it took years to coax the bacteria into producing even the simplest in this class of linked sugar molecules -; called sulfated glycosaminoglycans -;that are often used as drugs and nutraceuticals..