email article
Two proteins in blood plasma neurofilament light chain (NfL) and total tau were associated with cognition and neuroimaging outcomes, strengthening their potential as blood-based biomarkers of neurodegeneration, a large longitudinal study showed.
At baseline, NfL was more strongly associated with brain atrophy in multiple areas, white matter alterations, and changes in global cognition, reported Michelle Mielke, PhD, of the Mayo Clinic in Rochester, Minnesota. The combination of elevated NfL and total tau at baseline was more strongly associated with worse global cognition and memory loss and with neuroimaging measures, including temporal cortex thickness and increased number of infarcts.
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