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Treatment with an oncolytic immunovirotherapy alone or with radiation appeared safe and effective in a phase I study of children and adolescents with heavily pretreated high-grade glioma.
Eleven of 12 patients with progressive or recurrent supratentorial high-grade gliomas achieved radiographic, neuropathological, or clinical responses following treatment with G207, a genetically engineered herpes simplex virus (HSV) delivered intratumorally via catheter, Gregory Friedman, MD, of the University of Alabama at Birmingham, reported at the American Association for Cancer Research virtual meeting.
The treatment was associated with few toxicities, and the median overall survival (OS) reached 12.2 months (95% CI 8.0-16.4), which compares favorably to an established median OS of 5.6 months in the recurrent setting. Four of the 12 patients (36%) have survived beyond 18 months, exceeding the typical life expectancy for newly diagnosed cases.
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Ludwig Cancer Research scientists to present advances in immunotherapy, cancer metabolism
APRIL 10, 2021, NEW YORK – Ludwig Cancer Research released today the full scope of research to be presented by Ludwig-affiliated scientists at the April 9-14 American Association for Cancer Research (AACR) Annual Meeting, the first of two meetings which will be held online this year.
“The AACR Annual Meeting has long served as major opportunity for cancer researchers at all stages of their careers and from all over the world to meet, exchange ideas and forge collaborations to advance the study and treatment of cancer,” said Chi Van Dang, scientific director of the Ludwig Institute for Cancer Research and Editor-in-Chief of AACR’s Cancer Research journal. “The COVID-19 pandemic may have disrupted the physical gathering, but the intellectual exchange it enables will continue unimpeded. Ludwig and its scientists are excited about participating in that exchange.”
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