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Researchers study the digestion process of drug-loaded DNA nanostructures in real time
DNA nanotechnology - the research field using DNA molecules as building material - has developed rapidly during recent years and enabled the construction of increasingly complex nanostructures.
DNA nanostructures, such as DNA origami, serve as an excellent foundation for nanocarrier-based drug delivery applications, and examples of their use in medical treatments have already been demonstrated.
Although the stability of such DNA nanostructures under physiological conditions can be improved, little is known about their digestion by endonucleases, which, found everywhere in our blood and tissues, are responsible for destroying foreign DNA in our bodies.
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DNA nanotechnology - the research field using DNA molecules as building material - has developed rapidly during recent years and enabled the construction of increasingly complex nanostructures. DNA nanostructures, such as DNA origami, serve as an excellent foundation for nanocarrier-based drug delivery applications, and examples of their use in medical treatments have already been demonstrated. Although the stability of such DNA nanostructures under physiological conditions can be improved, little is known about their digestion by endonucleases, which, found everywhere in our blood and tissues, are responsible for destroying foreign DNA in our bodies.
To tackle this emerging question, a team of researchers from Aalto University (Finland), the University of Jyväskylä (Finland), Ludwig-Maximilian-Universität München (Germany) and Universität Paderborn (Germany) have found a way to study the endonuclease-driven digestion of drug-loaded DNA nanostructures in real time.
Best Readings in Full Duplex Wireless Communications
While conventional half-duplex wireless systems rely on transmitting and receiving in non-overlapping time slots or frequency channels, full duplex (FD) communications and the underlying self-interference cancellation (SIC) techniques may improve the attainable spectral efficiency while reducing latency. This is made possible by recent advances in antenna design and signal processing techniques specifically in multiple input multiple output systems, which make SIC of 80-110 dB possible. In fact, SIC has been demonstrated in applications requiring even more than 110 dB of interference cancellation. We expect that in the future, SIC technologies will enable not only FD communications, but also a variety of spectrum-sharing applications by creating radio technologies that are tolerant of adjacent and co-channel interference.