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Researchers develop new test to help fight deadly melanoma ANI | Updated: Feb 16, 2021 06:00 IST
Washington [US], February 16 (ANI): Researchers have developed a prototype test that can help identify if patients with deadly metastasised melanoma are likely to benefit from immunotherapy.
Australian researchers from QIMR Berghofer Medical Research Institute conducted the study. Details about the test and the research have been published on Monday (local time) in Clinical Cancer Research, a journal of the American Association for Cancer Research.
The prototype test detects levels of the protein LC3B on cancer cells. High levels of LC3B are associated with better patient responses to a form of treatment known as checkpoint inhibitor immunotherapy.
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Dairy farmer Peter Wehl is remembered by his family as a big-hearted man who always dreamed of taking his grandchildren camping.
But the discovery of a spot behind his ear dashed those dreams.
Mr Wehl had a level four melanoma removed after it was discovered during a routine skin check.
The late Peter Wehl (centre) and his wife Heather with (from left) son-in-law Ben Cottrell, granddaughter Madeline Cottrell, Alice Cottrell and grandson James Cottrell.
His daughter Alice Cottrell said the family waited nervously for five years, the time given by doctors for Mr Wehl to get the all-clear. He got it in 2013.
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Preview above: Insight finds out how Australians are managing their chronic pain. Full ep. on SBS On Demand.
At her worst, Amy O’Sullivan was spending half her time in a wheelchair, relying on her family to help her walk, eat, shower and more. For her family, they were left on tenterhooks, going to bed each night not knowing if their daughter would live to see another day.
From the age of 19, O’Sullivan began to suffer from a host of chronic conditions. These conditions were initially manageable and O’Sullivan carved out a career as a fitness professional. But slowly, her symptoms increased in severity and she began to experience extreme exhaustion, nausea, hand tremors, bone pain, cognitive decline and more. Then in 2013 her health took a turn for the worse.
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Researchers have discovered how a protein linked to Alzheimerâs disease uses the brainâs own cells as a âTrojan horseâ to spread.
The protein, called tau, is present in healthy brain cells and is used by the brain as part of its normal function but is also thought to be connected to the neuron âtanglesâ, which are the hallmark of Alzheimerâs and other dementias.
Researchers have identified how tau protein spreads around the brain to contribute to Alzheimerâs disease.
Credit:Dr Juan Polanco, UQ
The team from the Queensland Brain Institute at UQ have been trying to find how the protein spreads through the brain after an initial build-up, eventually causing these tangles.