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 E-Mail An experimental treatment can essentially reverse type 1 diabetes in certain types of laboratory mice, according to a series of studies led by University of Utah Health scientists. An injection of the therapeutic agent converts cells that normally control glucose production into ones that generate insulin. The researchers say giving the animals a single dose of a human antibody that suppress the actions of glucagon, a hormone involved in glucose regulation, sparked a remarkable transformation in the pancreas, leading to a nearly 7-fold increase in insulin cell mass and the suppression of diabetic symptoms. These animals go from requiring insulin injections to never requiring a diabetes treatment again. They maintain normal blood glucose long after we stop the treatment, says William L. Holland, Ph.D., the study s corresponding author and a U of U Health assistant professor of Nutrition and Integrative Physiology. What this implies for millions of people who have type

Vanderbilt universityUnited statesUniversity of texas southwestern medical centerBaylor college of medicineWilliaml hollandNational institute of diabetesVanderbilt university medical centerNu healthUniversity of utah healthAdministration north texas health care systemDiabetes research foundationLilly research laboratoriesChildren nutrition research centerProceedings of the national academy sciencesTouchstone diabetes centerUtah health