Eight Western Lowland Gorillas at US safari park down with COVID-19
downtoearth.org.in - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from downtoearth.org.in Daily Mail and Mail on Sunday newspapers.
美의사당 난입 후폭풍…의원 중 코로나 확진자 속출
donga.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from donga.com Daily Mail and Mail on Sunday newspapers.
Trojan Horse Antidotes Designed to Neutralize Lethal Botulinum Toxin
January 11, 2021
Two research groups have designed chimeric fusion proteins that constitute a new “trojan horse” approach to neutralize lethal botulinum toxins.
Botulinum neurotoxins (BoNTs) a family of bacterial toxins with seven major serotypes (BoNT/A to BoNT/G) are classified by the United States Centers for Disease Control and Prevention (CDC) as one of the most dangerous bioterrorism agents. BoNTs infiltrate into motor neurons, block neurotransmitter release, and stop essential functions such as breathing.
Chimeric therapeutic fusion protein created by fusing a single-domain antibody against BoNT/A with the delivery platform (yellow: nanobody; blue: BoNT/X light chain and translocation domain; red: BoNT/A receptor-binding domain) [Source: Min Dong]“It’s not killing the neurons, but it silences them,” said Konstantin Ichtchenko, PhD, assistant professor, department of biochemistry and molecular p