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Oxygen therapy may improve hypoxia-induced B cell abnormalities in COVID-19 Researchers in the United States have demonstrated early and persistent B cell abnormalities in patients with moderate or severe coronavirus disease 2019 (COVID-19) that may be largely driven by hypoxia. Given that the B cell response is a crucial part of the host immune defense against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent of COVID-19 – these deficits could have a significant impact on the disease course, says Kenneth Smith from the University of Cambridge and colleagues. “Hypoxia might contribute to B cell pathology in COVID-19 and in other hypoxic states,” writes the team. “Through this mechanism, it may impact on COVID-19 outcome, and be remediable through early oxygen therapy.”

United statesUnited kingdomKenneth smithHippel lindauSally robertsonKateryna kon shutterstockUniversity of cambridgeKateryna konHypoxia inducible factorsVon hippel lindauஒன்றுபட்டது மாநிலங்களில்ஒன்றுபட்டது கிஂக்டம்கெநெத் ஸ்மித்ஹிப்பல் லிண்டாவுசாலி ராபர்ட்சன்பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ்