From the “Ethically Dubious” file, which is in the “What could possibly go wrong?” filing cabinet, comes the news that researchers have grown mouse embryos outside of a mouse womb and kept them growing for 12 days – which would be about the length of the first trimester for a human embryo. Speaking of human embryos – the researchers are already discussing growing them outside of the womb for much longer than the few days embryos grow at invitro fertilization clinics before being implanted in a mother or destroyed. Is this the start of a brave new world, the end of ethics, the plot of the ultimate dystopian horror movie … or something far more unimaginable?
Researchers have grown human embryos from skin cells What does that mean, and is it ethical?
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Ethical questions raised by blastocyst breakthrough
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Credit: Monash University
AUSTRALIAN - LED INTERNATIONAL RESEARCH TEAM GENERATES THE FIRST MODEL OF EARLY HUMAN EMBRYOS FROM SKIN CELLS
In a discovery that will revolutionize research into the causes of early miscarriage, infertility and the study of early human development - an international team of scientists led by Monash University in Melbourne, Australia has generated a model of a human embryo from skin cells.
The team, led by Professor Jose Polo, has successfully reprogrammed these fibroblasts or skin cells into a 3-dimensional cellular structure that is morphologically and molecularly similar to human blastocysts. Called iBlastoids, these can be used to model the biology of early human embryos in the laboratory.
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This lab-grown ball of human cells shares many similarities with 5-day-old human embryos. UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER
Researchers re-create key human embryo stage in lab
Mar. 17, 2021 , 12:25 PM
A human embryo at the blastocyst stage is smaller than the tip of a ballpoint pen and may contain fewer than 100 cells, but this developmental waypoint has long puzzled and vexed biologists and physicians. Many miscarriages occur during this stage, for example, and a blastocyst can also split to create twins. Now, multiple research groups have found ways to mimic blastocysts, coaxing lab-grown human cells to form clusters that closely resemble the true thing.