In the current study, DDR1 has been identified as a cancer-associated receptor tyrosine kinase that is highly expressed in several malignancies relative to normal tissues.
29 As an important receptor, DDR1 can bind all types of collagens and could influence their signalling upon collagen stimulation.
30 It has been reported that the phosphorylation of DDR1 could activate the WNT/β-catenin and AKT/mTOR signaling to drive cancer cell metastasis and progression.
31,32 We observed that pY792 DDR1, the active form of DDR1, was upregulated by COL5A2 overexpression in HCT116 and SW620 cells (Figure 4D).
These observations indicate that
COL5A2 expression upregulates WNT/β-catenin and PI3K/mTOR signaling via binding DDR1 with phosphorylation and activation of this receptor, which might contribute to CRC tumorigenesis or progression.
North America GMP Cytokines Market to See a Huge Rise during 2020-2027 with an improve in Revenue of US$ 66.92 million | Business Market Insights
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The Business Market Insights provides you regional research analysis on
North America GMP Cytokines Market and forecast to 2027. The research report provides deep insights into the regional market revenue, parent market trends, macro-economic indicators, and governing factors, along with market attractiveness per market segment. The report provides an overview of the growth rate of the North America GMP Cytokines market during the forecast period, i.e., 2020–2027.
The North America GMP cytokines market is expected to reach US$ 66.92 million by 2027 from US$ 35.49 million in 2019; it is estimated to grow at a CAGR of 8.3% from 2020 to 2027.
Predicted N Terminal: Met
Molecule Mass: The recombinant human IL6 consisting of 184 amino acids migrates with an apparent molecular mass of 20.95 kDa as estimated in SDS-PAGE under reducing conditions.
Formulation
Users should contact Sino Biological for any concerns or special needs
Typically, 0.01% Tween80, 5% to 8% trehalose, and mannitol are added as protectants prior to lyophilization
Shipping: Normally, recombinant proteins are offered as lyophilized powders shipped at ambient temperature. Huge packages of recombinant proteins are shipped as frozen liquid. They are shipped out with blue ice unless specified otherwise by customers.
Stability and storage
Samples are stable for up to a time of 12 months from date of receipt at −20 ℃ to −80 ℃
Molecule mass
The recombinant Chinese hamster PLBL2 contains a total of 559 amino acids and estimates a molecular mass of 63.3 kDa. Under reducing conditions, the recombinant Chinese hamster PLBD2 migrates as an approximately35.9, 43.8, 65.3 KDa band in SDS-PAGE.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Customers can contact Sino Biological for any concerns or unique needs. Generally, 0.01% Tween80 and 5% to 8% trehalose and mannitol are added as protectants prior to lyophilization. Customers can refer to the specific buffer data provided in the hard copy of CoA.
Shipping
Recombinant proteins are generally delivered as lyophilized powder that is shipped at ambient temperatures. Large recombinant protein packages are delivered as frozen liquid and are shipped with blue ice unless specified by customers.
10,000 doses of CanSino vaccine gathering dust in Karachi
Top Story
April 17, 2021
KARACHI: At a time when Pakistan is desperately looking for COVID-19 vaccines to inoculate millions of people, 10,000 doses of single-dose Chinese vaccine Convidecia, imported by a private firm in Pakistan, are lying useless at a warehouse in Karachi, at least for the last 10 days as Drug Regulatory Authority of Pakistan (DRAP) is awaiting ‘some documents’ to release the consignment, The News has learnt.
“10,000 doses of Convidecia vaccine, developed by the CanSino Biologics Inc, had arrived in Karachi at least 10 days ago. This shipment was imported by a private firm AJM Limited and it was to be supplied to three hospitals in the country but it has not yet been released by the DRAP due to red-tapism,” an official of the National Health Services, Regulations and Coordination (NHS,R&C) told The News on Friday.