Influenza A Virus Discovered in Heart Muscle Tissue Causing Damage Long After It Has Cleared from the Lungs
Strategies to inhibit necrotic cell death or to prevent mitochondrial damage should be pursued as possible therapies to reduce cardiac damage during influenza infections
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ROCKVILLE, Md., Jan. 27, 2021 /PRNewswire/ Scientists from the J. Craig Venter Institute (JCVI) have discovered that Influenza A virus (IAV) is found in heart tissue after it has been cleared from the lungs in mouse models. Live IAV present during convalescence does not actively replicate, preventing development of antiviral inflammatory responses, thus cloaking it from the immune system. Undetected, the virus continues to disrupt mitochondrial function, causing a metabolic breakdown and promoting cell death.
SAN ANTONIO and BOSTON - Study findings released Tuesday in the
Journal of the American Medical Association (JAMA) hold both good news and bad news about transient ischemic attacks (TIAs), which are harbingers of subsequent strokes.
Sudha Seshadri, MD, professor of neurology at The University of Texas Health Science Center at San Antonio and director of the university s Glenn Biggs Institute for Alzheimer s and Neurodegenerative Diseases, is senior author of the study and senior investigator of the Framingham Heart Study, from which the findings are derived. She said the extensive follow-up of Framingham participants over more than six decades enabled the study to present a more-complete picture of the risk of stroke to patients after a TIA.
BASIC RESEARCH
Fighting COVID-19 with the Body’s Clock
The fledgling field of chronotherapy timing drugs to a patient’s
circadian rhythms may yet come to the aid of those at risk from the virus. by Sarah DiGiulio
Even as the COVID-19 vaccines roll out, current cases of the disease remain on the rise. Better ways to treat the infected are still sorely needed, and that holds especially true for countries where resources are limited and vaccinations are likely to move more slowly. So it is with interest that many are considering a resource as free as the rising and setting of the sun.
Send Brett Trelfa has been named chief information officer at Arkansas Blue Cross & Blue Shield in Little Rock.
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COVID-19 and the brain: What do we know so far?
Written by Ana Sandoiu on January 25, 2021 Fact checked by Zia Sherrell, MPH
What do we currently know about the effects of SARS-CoV-2 on the brain? In this feature, we round up the emerging evidence.
Sutthaburawonk/Getty Images
All data and statistics are based on publicly available data at the time of publication. Some information may be out of date. for the most recent information on the COVID-19 pandemic.
How does SARS-CoV-2, the virus that causes COVID-19, affect the human brain? Recent studies have given us clues, shedding light on why COVID-19 can be so severe for some people and why the symptoms can last a long time.