Avian influenza A(H7N3) virus on commercial turkey farms in NC & SC, USA Emerging Infectious Diseases. 2020;26(12):2966-2969. 13 December, 2020 Highly pathogenic avian influenza viruses (HPAIVs) have devastating impacts on the poultry industries. With infections in poultry, H5 and H7 low-pathogenicity avian influenza viruses (LPAIVs) have spontaneously mutated into HPAIVs by different mechanisms, one of which is acquisition of basic amino acids at the hemagglutinin (HA) cleavage site. In March 2020, an outbreak of LPAIV H7N3 occurred in turkey farms, affecting 11 premises in North Carolina and 1 in South Carolina, USA. The initial decision to depopulate LPAIV-affected flocks was based on a risk assessment that included the location of affected premises, the poultry density in the area, and the presence of a basic amino acid substitution at the cleavage site among the initial LPAIV detections (PEKPKTR/GLF; substitution sequence is highlighted).
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