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Wednesday, 07 Apr 2021 05:59 PM MYT
In pre-clinical tests, the team reported that the chemotherapeutic drug, Topotecan, reduces the morbidity and mortality of SARS-CoV-2 infection. Picture courtesy of Savushkin / Istock.com
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SINGAPORE, April 7 An international research collaboration involving researchers from Singapore and the United States has found that a widely available and inexpensive drug used for cancer treatment could potentially be used in the treatment of Covid-19.
In pre-clinical tests, the team reported that the chemotherapeutic drug, Topotecan, reduces the morbidity and mortality of SARS-CoV-2 infection by inhibiting the expression of inflammatory genes in the lungs of laboratory models of Covid-19.
SINGAPORE - A drug used in cancer treatment can treat patients with moderate to severe forms of Covid-19, according to a study by Singapore and US researchers.
They found that Topotecan, which is used in chemotherapy, reduced the severity and death rates of infection by Sars-Cov-2 - the virus causing Covid-19 - by suppressing inflammation in the lungs of laboratory animals.
Patients with moderate to severe forms of Covid-19 suffer from inflammation, a result of an overactive, abnormal immune response. In some patients, an exaggerated immune response - typically occurring in the lungs - can flood the infected area with white blood cells, resulting in severe inflammation, tissue damage and often death.
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Cancer drug may be able to treat inflammation caused by COVID-19 virus: Singapore-US study
Dr Anand Jeyasekharan with a vial of Topotecan, a cancer drug that could potentially be used in the treatment of COVID-19. (Photo: National University Cancer Institute, Singapore)
07 Apr 2021 09:50PM) Share this content
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SINGAPORE: A widely available and inexpensive drug used for cancer treatment could potentially be used in the treatment of COVID-19, according to a study by Singapore and US researchers.
They found that the chemotherapeutic drug, called Topotecan, reduced the severity and death rates of infection by the virus that causes COVID-19, by suppressing inflammation in the lungs of laboratory animals.
Anti-cancer drug can treat Covid-19, Singapore-US study shows thestar.com.my - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thestar.com.my Daily Mail and Mail on Sunday newspapers.