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 E-Mail GRAND RAPIDS, Mich. (JUNE 10, 2021) Much like a supply truck crossing the countryside, the misfolded proteins that damage neurons in Alzheimer s disease travel the roads of the brain, sometimes stopping and sometimes re-routing to avoid roadblocks, reports a study published in The findings shed light on how tau proteins, which form tangled clumps that damage brain cells in Alzheimer s, move through the brain. The study also provides new insights into why some areas of the brain are more vulnerable to damage than other areas. While the interconnected structure of the brain is essential to its function, these misfolded proteins commandeer that structure to travel through the brain and cause progressive degeneration, said Michael X. Henderson, Ph.D., an assistant professor at Van Andel Institute and corresponding author of the study. By understanding how these proteins travel through the brain and what causes certain neurons to be at risk for damage, we can develop n

United statesMichaelx hendersonJohnq trojanowskiModupef olufemiRonaldj gathaganEli cornblathLakshmi changolkarHannahj brownDanielles bassettHowardl liAlfredp sloan foundationStroke of the national institutes healthNational science foundationPaulg allen foundationVan andel institute bioinformaticsUniversity of pennsylvania