Page 5 - பரந்த தண்டு செல் ஆராய்ச்சி மையம் News Today : Breaking News, Live Updates & Top Stories | Vimarsana

New Technique in MS Research May Help Isolate, Characterize T-cells

T-cells are a type of white blood cell that recognizes fragments of molecules, called antigens, through specific membrane receptors (TCRs). Each of these cells has unique TCRs that recognize a specific antigen. This antigen can be, for instance, a fragment of a particular virus or bacterium, a specific type of cancer cell, or, in the case of autoimmune diseases, a particular molecule of a person’s own body promoting inadequate attacks against it. When a T-cell encounters the antigen its receptor recognizes, it produces many copies of itself and instructs other immune cells to attack the same antigen. “They’re both the effectors and organizers of the body’s adaptive immune response, which means they can be used as therapeutics and studying their dynamics can shed light on overall immune activity,” Pavlo Nesterenko, the study’s first author and a graduate student at UCLA, said in a university press release.

Marta figueiredoOwen wittePavlo nesterenkoUniversity of lisbonBroad stem cell research centerLeiden university medical centerProceedings of the national academy sciencesJonsson comprehensive cancer centerBiomedical sciencesStem cell research centerNational academyStem cell researchComprehensive cancer centerDevelopmental biologyMedical microbiologyInfectious diseases

UCLA scientists develop method to more efficiently isolate and identify rare T cells

Credit: UCLA Broad Stem Cell Research Center Scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a technique that will enable researchers to more efficiently isolate and identify rare T cells that are capable of targeting viruses, cancer and other diseases. The approach could increase scientists understanding of how these critical immune cells respond to a wide range of illnesses and advance the development of T cell therapies. This includes immunotherapies that aim to boost the function and quantity of cancer or virus-targeting T cells and therapies intended to regulate the activity of T cells that are overactive in autoimmune diseases such as diabetes and multiple sclerosis.

Hal gabaEpstein barrOwen wittePavlo nesterenkoStem cell researchNational cancer instituteBroad stem cell research centerJonsson comprehensive cancer centerFund for cancer stem cell reseProceedings of the national academy sciencesParker institute for cancer immunotherapyEdythe broad centerRegenerative medicineNational academyComprehensive cancerParker institute

High-Throughput Mitochondria Transfer Device Developed

High-Throughput Mitochondria Transfer Device Developed December 31, 2020 Source: SCIEPRO/SCIENCE PHOTO LIBRARY/Getty Images Researchers from the UCLA Jonsson Comprehensive Cancer Center say have developed a simple, high-throughput method for transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells. This approach enables researchers to tailor a key genetic component of cells, to study and potentially treat debilitating diseases such as cancer, diabetes, and metabolic disorders. Cell Reports, and it describes how the new UCLA-developed device, called MitoPunch, transfers mitochondria into 100,000 or more recipient cells simultaneously, which is a significant improvement from existing mitochondrial transfer technologies. The device is part of the continued effort by UCLA scientists to understand mutations in mitochondrial DNA by developing controlled, manipulative approaches that improve the function of human cells or model human mitochondrial

Pei yu eric chiouHsiang wuAlexander patanananMichael teitellAlexander sercelBroad stem cell research centerDavid geffen school of medicineJonsson cancer centerHenry samueli school of engineeringJonsson comprehensive cancer centerComprehensive cancer centerDesired genetic combinationsCell reportsDavid geffen schoolSamueli schoolApplied science

Scientists develop high-throughput mitochondria transfer device

Scientists develop high-throughput mitochondria transfer device
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Pei yu eric chiouHsiang wuAlexander patanananMichael teitellAlexander sercelAlexandern patanananBroad stem cell research centerImmunitybio incDavid geffen school of medicineJonsson cancer centerHenry samueli school of engineeringJonsson comprehensive cancer centerComprehensive cancer centerCell reportsDavid geffen schoolSamueli school

Scientists develop high-throughput mitochondria transfer device — Agenparl

Scientists develop high-throughput mitochondria transfer device — Agenparl
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United statesPei yu eric chiouHsiang wuAlexander patanananMichael teitellAlexander sercelUs air force office of scientific researchAmerican heart associationBroad stem cell research centerImmunitybio incDavid geffen school of medicineJonsson cancer centerNational institutes of healthHenry samueli school of engineeringCell reportsDavid geffen school