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GSK-3 inhibitors show promise in treating coronavirus infections

GSK-3 inhibitors show promise in treating coronavirus infections Researchers in the United States have suggested a new approach to treating infection with coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19). The study showed that inhibiting phosphorylation of a key structural protein expressed on coronaviruses impaired SARS-CoV-2 infection in human lung epithelial cells. The team used inhibitors of the host cell protein glycogen synthase kinase 3 (GSK-3) to block phosphorylation of the SARS-CoV-2 nucleocapsid protein that is essential for coronavirus replication. The researchers also demonstrated that the GSK-3 inhibitor lithium was associated with a significantly reduced risk for COVID-19

Penn named one of America s best large employers

Forbes recognized Penn Medicine and the University among the top 100 of its 2021 list. In early February, Forbes magazine honored America’s Best Employers 2021 500 large employers and 500 midsize employers across 25 industry sectors. Penn Medicine came in at No. 90. and the University was ranked No. 92. To establish this year’s list, Forbes teamed up with market research company Statista to pinpoint the companies that employees liked best. The employees were consulted anonymously through several online panels. The evaluation was based on direct and indirect recommendations from employees who were asked to rate their willingness to recommend their own employers to friends and family.

Semaglutide paired with intensive behavioral therapy showed triple weight loss vs placebo

 E-Mail PHILADELPHIA A second study of the injectable anti-obesity medication, semaglutide, has confirmed the large weight losses reported in a study earlier this month, establishing the reliability and robustness of this new drug. With obesity affecting more than 40 percent of American adults, the findings could have a major impact on weight management in primary care and other settings. The study is published today in the Journal of the American Medical Association. The 68-week study was conducted at 41 sites in the United States from August 2018 to April 2020 and was designed to boost total weight loss with semaglutide by combining the medication with a more intensive diet and physical activity program than what was used in the STEP 1 trial, published online February 10th in the

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