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 E-Mail University of Minnesota Twin Cities researchers in the Department of Chemistry have created a new polymer to deliver DNA and RNA-based therapies for diseases. For the first time in the industry, the researchers were able to see exactly how polymers interact with human cells when delivering medicines into the body. This discovery opens the door for more widespread use of polymers in applications like gene therapy and vaccine development. The research is published in the Proceedings of the National Academy of Sciences ( PNAS), a peer-reviewed multidisciplinary scientific journal. Gene therapy involves altering the genes inside the body s cells to treat or cure diseases. It requires a carrier that packages the DNA to deliver it into the cell oftentimes, a virus is used as a carrier. Packaging of nucleic acids is also used in vaccines, such as the recently developed messenger RNA (mRNA) COVID-19 vaccine, which is enclosed in a lipid.

Craig van bruggenRenee frontieraDavid punihaoleTheresa reinekeAndrew schmitzAllison keithUniversity of minnesota twin citiesNational institutes of healthCollege of scienceNational science foundationMcknight university professorDepartment of chemistryProceedings of the national academy sciencesUniversity of minnesota medical schoolMinnesota twin citiesNational academy