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 E-Mail Researchers at Baylor College of Medicine show that analysis of the proteomics, or all the protein data, from aggressive human cancers is a useful approach to identify potential novel therapeutic targets. They report in the journal Oncogene, the identification of proteomic signatures that are associated with clinical measures of aggressive disease for each of the seven cancer types studied. Some signatures were shared between different types of cancer and included cellular pathways of altered metabolism. Importantly, experimental results provided proof-of-concept that their proteomics analysis approach is a valuable strategy to identify potential therapeutic targets. There are two notable aspects of this study. One is that we explored the proteomic landscape of cancer looking for proteins that were expressed in association with aggressive forms of cancer, said co-corresponding author Dr. Chad Creighton, professor of medicine and co-director of Cancer Bioinformatics

United statesBaylor college of medicineDarshans chandrashekarYiqun zhangDiana monsivaisSooryanarayana varamballyYasmin vasquezRamyap masandFengju chenJohnc faverMichaele scheurerMartinm matzukBurroughs wellcome fundUniversity of texas md anderson cancer centerNational institutes of healthClinical proteomic tumor analysis consortium