Lab animals deficient in vitamin D crave and become dependent on opioids, which is curbed when normal levels of the vitamin are restored. Human health records indicate that people with low vitamin D are more likely to use and misuse opioids. Study results suggest a potential role for vitamin D supplementation in fighting opioid addiction.
Studies in Mice Help to Explain Why Redheads Have Different Pain Thresholds
April 6, 2021
Source: Photo by Colton Sturgeon on Unsplash
New research led by investigators at Massachusetts General Hospital (MGH) has offered up new insights into why people with red hair exhibit altered sensitivity to certain kinds of pain. The results of studies in mice with loss of melanocortin 1 receptor (MC1R) function could help point to new ways to manipulate the body’s natural mechanisms for controlling pain perception, for example, by designing new medications that inhibit receptors that are involved in sensing pain.
“Our ongoing work is focused on elucidating how additional skin-derived signals regulate pain and opioid signaling,” said Lajos V. Kemény, MD, PhD, a research fellow in Dermatology at MGH, who is co-senior author of the team’s paper, in
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A new study published in the journal Science Advances explains why individuals with red hair (the rarest of the natural hair colors in humans) might exhibit altered pain tolerance.
The work, led by researchers from Massachusetts General Hospital (MGH) has validated a known phenomenon that links the pigmentation of one s hair to altered sensitivity to certain types of pain. These findings describe the mechanistic basis behind earlier evidence suggesting varied pain thresholds in different pigmentation backgrounds, says David Fisher, MD, PhD, director of the Mass General Cancer Center s Melanoma Program in a statement. Understanding this mechanism provides validation of this earlier evidence and a valuable recognition for medical personnel when caring for patients whose pain sensitivities may vary.
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