Researchers are studying and raising awareness about the role of sex in the efficacy of vaccines that use nanomedicine, including some COVID-19 vaccines.
If there’s one take-home message for the general public about the coronavirus vaccines approved in the US, it’s that they are remarkably effective.
But Michigan State University’s Morteza Mahmoudi is raising awareness about an important subtlety: The vaccines developed by Moderna and Pfizer-BioNTech appear to work slightly better for males than for females.
“We need to monitor these sex differences and report them to the scientific community and the public.”
Both vaccines use tiny orbs, or nanoparticles, to deliver their active ingredients to cells in our immune systems. For years, Mahmoudi has been studying how and why nanomedicines therapies that use nanoparticles can affect patients differently based on their sex and he believes this could be a factor with the vaccines.
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New techniques are showing how tiny diagnostics, therapeutics interact with human biomolecules like never before
MSU Assistant Professor Morteza Mahmoudi
An international team of researchers led by Michigan State University’s Morteza Mahmoudi has developed a new method to better understand how nanomedicines emerging diagnostics and therapies that are very small yet very intricate interact with patients’ biomolecules.
Medicines based on nanoscopic particles have the promise to be more effective than current therapies while reducing side effects. But subtle complexities have confined most of these particles to research labs and out of clinical use, said Mahmoudi, an assistant professor in the Department of Radiology and the Precision Health Program.