A new gene therapy has been shown to reverse some of the effects of ageing in mice and extend their lifespans by up to a quarter.
Chinese researchers used CRISPR-Cas9, a powerful gene-editing tool, to inactivate a gene called KAT7, which is a key contributor to cellular ageing.
An injection of a viral vector encoded for KAT7 reduced what is known as cellular senescence – the end of cell division, which organisms need to grow and replenish tissue.
Although experiments were conducted with mice in the lab, the experts think their findings may one day contribute to similar treatments for humans.
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2National Centre for Indigenous Genomics, Australian National University, Canberra, ACT, Australia
3Department of Pharmacology, Dalhousie University, Halifax, NS, Canada
4Precision Medicine, Platform on Shaping the Future of Health and Healthcare, World Economic Forum, San Francisco, CA, United States
5Institute of Genetics, Canadian Institutes of Health Research, Government of Canada, Ottawa, ON, Canada
6Human Metabolomics, North-West University, Potchefstroom, South Africa
7Facultad de Medicina, Center for Genetics and Genomics, Clinica Alemana Universidad del Desarrollo, Santiago, Chile
8Institute of Health Management, Southern Medical University, Guangdong, China
9KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa
10Rare Diseases South Africa, Johannesburg, South Africa