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Study: Women with breast cancer diagnosed over 65 should be offered hereditary cancer genetic testing

Study: Women with breast cancer diagnosed over 65 should be offered hereditary cancer genetic testing A new study by Fergus Couch, Ph.D., of Mayo Clinic Cancer Center, along with collaborators from the CARRIERS consortium, suggests that most women with breast cancer diagnosed over 65 should be offered hereditary cancer genetic testing. The study was published Thursday, July 22, in the Journal of Clinical Oncology. Dr. Couch says that women over 65 rarely qualify for hereditary cancer genetic testing based on current testing guidelines because they are thought to exhibit low rates of genetic mutations in breast cancer genes. Most studies of breast cancer genes have not looked at older women, those who were diagnosed over the age of 65, says Dr. Couch. He says these studies have mainly tested women with a strong family history of breast or ovarian cancer rather than those in the general breast cancer population. By studying older women from the general breast cancer population,

Older Women with Breast Cancer May Benefit from Genetic Testing

Older Women with Breast Cancer May Benefit from Genetic Testing
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Research suggests women over 65 be offered hereditary cancer genetic testing

Research suggests women over 65 be offered hereditary cancer genetic testing
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Lung cancer patients should be screened for MET oncogene amplification, research suggests

Lung cancer patients should be screened for MET oncogene amplification, research suggests Research by investigators at Mayo Clinic Cancer Center suggests that physicians should screen patients with lung cancer for MET amplification/overexpression before determining a treatment strategy. Their findings are published Cancer Discovery, a journal of the American Association for Cancer Research. In our research we found several lung cancer cases that were not responsive to standard chemotherapy, says Zhenkun Lou, Ph.D., a cancer researcher at Mayo Clinic. Because these lung cancers were positive for PD-L1, a protein that allows some cells to escape attack by the immune system, we then tried treating these patients with anti-PD1 immunotherapy to relieve PD-L1 mediated immune suppression, however this treatment also failed.

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