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The emergence of “variants of concern” has raised questions about our long-term immunity to the coronavirus. Will the antibodies we make after being infected with or vaccinated against the dominant lineage, called D614G, protect us against future viral variants?
To answer this question, scientists have been examining how our antibody responses to the coronavirus develop over time. Several studies have recently compared the difference between antibodies produced straight after a coronavirus infection and those that can be detected six months later. The findings have been both impressive and reassuring.
Although there are fewer coronavirus-specific antibodies detectable in the blood six months after infection, the antibodies that remain have undergone significant changes. Researchers have tested their ability to bind to proteins from the new coronavirus variants and found that 83% of the “mature” antibodies were better at recognizing the variants. A recent preprint (a study t
Few Covid vaccines prevent infection â but here s why that s not a problem
There is a subtle yet important difference between preventing disease and preventing infection
Daniel Smith
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Virus replication takes place inside cells
Blocking entry to the cells prevents more of the virus being made
The latest results from the phase 3 Covid-19 vaccines trials have been very positive.
These have shown that vaccinating people with the gene for SARS-CoV-2 spike protein can induce excellent protective immunity.
The spike protein is the focus of most Covid-19 vaccines as it is the part of the virus that enables it to enter our cells.
Virus replication only happens inside cells, so blocking entry prevents more virus being made.
If a person has antibodies that can recognise the spike protein, this should stop the virus in its tracks.