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Relationship between neuropsychiatric symptoms and Alzheimer disease pathology: An in vivo positron emission tomography study

Relationship between neuropsychiatric symptoms and Alzheimer disease pathology: An in vivo positron emission tomography study
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Alzheimer disease neuroimaging initiativeமுதுமறதி நோய் நியூரோஇமேஜிங் முயற்சி

Duke researchers find possible indicator of Alzheimer s long before symptoms arise

by Sarah Avery February 16, 2021 . DURHAM – People who have a gene variant associated with an increased risk of developing Alzheimer’s disease also tend to have changes in the fluid around their brain and spinal cord that are detectable years before symptoms arise, according to new research from Duke Health. The work found that in people who carry the APOE4 gene variant, which is found in roughly 25 percent of the population, the cerebrospinal fluid contains lower levels of certain inflammatory molecules. This raises the possibility that these inflammatory molecules may be collecting in the brain where they may be damaging synapses, rather than floating freely in the cerebrospinal fluid.

Michaelj devinneyAlexanders roeslerJenniferl modliszewskiJohn parkStacey chungDavidl corcoranAnn busselArthur moseleyJeffreyn browndykeAshley hallVictor caiKeithw vandusenShayan smaniMary cooterMichaelw lutzRuthk broad foundation at duke university

Spinal Fluid of People with Alzheimer s Risk Gene Signals Inflammation

Spinal Fluid of People with Alzheimer’s Risk Gene Signals Inflammation People who have a gene variant associated with an increased risk of developing Alzheimer’s disease also tend to have changes in the fluid around their brain and spinal cord that are detectable years before symptoms arise, according to new research from Duke Health. The work found that in people who carry the APOE4 gene variant, which is found in roughly 25 percent of the population, the cerebrospinal fluid contains lower levels of certain inflammatory molecules. This raises the possibility that these inflammatory molecules may be collecting in the brain where they may be damaging synapses, rather than floating freely in the cerebrospinal fluid.

Michaelj devinneyAlexanders roeslerJenniferl modliszewskiJohn parkStacey chungDavidl corcoranAnn busselArthur moseleyJeffreyn browndykeAshley hallVictor caiKeithw vandusenShayan smaniMary cooterMichaelw lutzRuthk broad foundation at duke university

Blood Biomarker May Predict Alzheimer s Disease Progression

Blood Biomarker May Predict Alzheimer s Disease Progression
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United statesVastra gotalands lanDavids knopmanAlzheimer disease neuroimaging initiativeUniversity of gothenburgMichael schMedscape medicalDisease neuroimaging initiativePreclinical alzheimer cognitive compositeAlzheimer disease assessment scaleCognitive subscaleHispanic whitesMedscape medical newsMayo clinicஒன்றுபட்டது மாநிலங்களில்முதுமறதி நோய் நியூரோஇமேஜிங் முயற்சி

New studies support blood test for early detection of Alzheimer s disease

New studies support blood test for early detection of Alzheimer s disease Molecular Psychiatry, Brain and JAMA Neurology researchers from the University of Gothenburg provide convincing evidence that an in-house developed blood test for Alzheimer s disease can detect the disease early and track its course, which has major implications for a potential use in clinical practice and treatment trials. This is an extremely dynamic research field right now, thanks to the technological development and seminal scientific progress in the past years. The dream scenario is to have a blood test for the early detection and screening of Alzheimer s disease up and running. That would give significantly more people in the world access to testing and future treatments , says Michael Schöll, associate professor and one of the senior authors.

Kaj blennowThomas karikariHenrik zetterbergAlzheimer disease neuroimaging initiativeSahlgrenska academyUniversity of gothenburgAlzheimer disease neuroimage initiativeMolecular psychiatryMichael schDisease neuroimage initiativeAlexis moscosoDisease neuroimaging initiativeBlood phosphorylated tauNeurofilament light chain with neurodegenerationAlzheimer diseaseதாமஸ் காரிகாரி