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Transcenta Continues to Push the Boundary of Cell Culture Productivity by Achieving > 6 g/L PER Day Volumetric Productivity in Continuous Perfusion Platform
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SUZHOU and HANGZHOU, China, March 16, 2021 /PRNewswire/ Transcenta, a global biotherapeutics company with fully-integrated capabilities in discovery, development and manufacturing of antibody-based therapeutics, today announced a major breakthrough in its continuous perfusion cell culture platform by achieving volumetric productivity of > 6 g/L per day while maintaining process and product quality attributes in a state of control for a 4-week culture. This productivity improvement represents a 15-fold increase in drug substance output per year when compared to same cell line in conventional fed-batch process (6 g/L over 14 days). At such high productivity, one 100L or 1,000L single use bioreactor can produce approximately 130 kg or 1.3 metric tons of total drug substanc
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