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BOSTON - During the development and progression of Alzheimer s disease, a protein called tau accumulates and spreads in the brain. Understanding the mechanisms behind tau spread and its consequences may point to new prevention and treatment strategies for Alzheimer s disease and other forms of dementia. New insights now come from research that was led by investigators at Massachusetts General Hospital (MGH) and involves an anesthetic known to affect cognitive function. The findings are published in
The scientists note that inflammation plays an important role in Alzheimer s disease, and microglia immune cells that reside in the brain are thought to be involved in this process by producing an inflammatory molecule called interleukin-6. To see if tau stimulates microglia to drive the development of Alzheimer s disease pathology, the MGH investigators and their colleagues conducted experiments with an inhaled anesthetic called sevoflurane. Their previous work showed that sev
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Boston - Pregnant women with symptomatic COVID-19 have a higher risk of intensive care unit admissions, mechanical ventilation and death compared to non-pregnant reproductive age women. Increases in preterm birth and still birth have also been observed in pregnancies complicated by the viral infection. The Centers for Disease Control and Prevention (CDC) recommended that people who are pregnant may choose to be vaccinated at their own discretion with their healthcare provider. However, pregnant and lactating women were not included in Phase 3 vaccine efficacy trials; thus, data on vaccine safety and immunogenicity in this population is limited.
In a new study from Beth Israel Deaconess Medical Center (BIDMC), specialists in the Department of Obstetrics and Gynecology and the Center for Virology and Vaccine Research evaluated the immunogenicity of COVID-19 mRNA vaccines in pregnant and lactating women who received either the Pfizer or Moderna COVID-19 vaccines. The researc
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BOSTON - During the development and progression of Alzheimer s disease, a protein called tau accumulates and spreads in the brain. Understanding the mechanisms behind tau spread and its consequences may point to new prevention and treatment strategies for Alzheimer s disease and other forms of dementia. New insights now come from research that was led by investigators at Massachusetts General Hospital (MGH) and involves an anesthetic known to affect cognitive function. The findings are published in
The scientists note that inflammation plays an important role in Alzheimer s disease, and microglia immune cells that reside in the brain are thought to be involved in this process by producing an inflammatory molecule called interleukin-6. To see if tau stimulates microglia to drive the development of Alzheimer s disease pathology, the MGH investigators and their colleagues conducted experiments with an inhaled anesthetic called sevoflurane. Their previous work showed that sev
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IMAGE: Dr. Malanga (right) and Dr. Tyson-Hudson (center) conduct a follow-up examination on a wheelchair user with spinal cord injury. view more
Credit: Kessler Foundation/Jody Banks
East Hanover, NJ. May 12, 2021. A team of specialists in regenerative rehabilitation conducted a successful pilot study investigating micro-fragmented adipose tissue (MFAT) injection for rotator cuff disease in wheelchair users with spinal cord injury. They demonstrated that MFAT injection has lasting pain-relief effects. The article, A pilot study to evaluate micro-fragmented adipose tissue injection under ultrasound guidance for the treatment of refractory rotator cuff disease in wheelchair users with spinal cord injury, (doi: 10.1080/10790268.2021.1903140) was published ahead of print on April 8, 2021, by the