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A graded dosing protocol allowed two patients with hypersensitivity reactions to the first dose of Moderna s COVID-19 vaccine to receive their second doses safely, researchers said.
The patients one with an immediate hypersensitivity reaction managed on site and one needing emergency department transport got divided second doses, reported S. Shahzad Mustafa, MD, of Rochester Regional Health in Rochester, New York, and colleagues
.
Three to four weeks after receiving the second dose, both patients had IgG antibodies against the spike protein of COVID-19, suggesting vaccination was efficacious despite the graded dosing protocol, they wrote in
Annals of Internal Medicine. One had no reaction to the second dose while the other experience some non-serious allergic symptoms.