Date Time
How circadian clock regulates liver genes in time and space
EPFL scientists have carried out the first comprehensive study of how genes in the liver perform their metabolic functions in both space and time of day. Monitoring almost 5000 genes at the level of the individual cell across a 24-hour period, the researchers have modelled how the circadian clock and liver functions crosstalk throughout the day in sync with the feeding-fasting cycle.
Nothing in biology is static. Biological processes fluctuate over time, and if we are to put together an accurate picture of cells, tissues, organs etc., we have to take into account their temporal patterns. In fact, this effort has given rise to an entire field of study known as “chronobiology”.
Study monitors spatial shifts of liver gene expression in relationship to the circadian clock
Nothing in biology is static. Biological processes fluctuate over time, and if we are to put together an accurate picture of cells, tissues, organs etc., we have to take into account their temporal patterns. In fact, this effort has given rise to an entire field of study known as chronobiology .
The liver is a prime example. Everything we eat or drink is eventually processed there to separate nutrients from waste and regulate the body s metabolic balance. In fact, the liver as a whole is extensively time-regulated, and this pattern is orchestrated by the so-called circadian clock, our body s internal metronome, as well as biochemical signals and eating rhythms.
EPFL scientists have carried out the first comprehensive study of how genes in the liver perform their metabolic functions in both space and time of day. Monitoring almost 5000 genes at the level of the individual cell across a 24-hour period, the researchers have modelled how the circadian clock and liver functions crosstalk throughout the day in sync with the feeding-fasting cycle.