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Dr H. Michael Shepard, CEO and CSO of Enosi Life Sciences, discusses the similarities between cancer and autoimmune diseases, highlighting how this knowledge could be used to enhance treatments. The progression of cancer and autoimmune diseases are both characterised by intense inflammation and both diseases recruit immune cells to quell the escalating inflammation. In cancer, the recruitment of these cells, primarily regulatory (suppressor) T cells, attempt to resolve the ongoing inflammation with the result of turning down anticancer immunity. In autoimmune diseases, the constant stimulation of inflammation (immune reaction against the body’s own tissues) overwhelms the regulatory T cells. In both diseases other immune cells can also suppress immunity, with similar results as regulatory T cells. Furthermore, the biochemical pathways that regulate immune cell function are the same in both diseases.

H michael shepardBoard member of enosi life sciencesWorld health organizationLasker debakey clinical medical researchUs national cancer instituteEnosi life sciencesHarvard medical school warren alpert prizeCancer instituteCancer genome atlasChief executive officerChief scientific officerBoard memberEnosi lifeDebakey clinical medical researchCancer sitesCancer stat facts