SwabSeq platform offers a potential solution for massive COVID-19 testing
In an article appearing in Nature Biomedical Engineering, a team of scientists from the UCLA David Geffen School of Medicine and UCLA School of Engineering report real-world results on SwabSeq, a high-throughput testing platform that uses sequencing to test thousands of samples at a time to detect COVID-19. They were able to perform more than 80,000 tests in less than two months, with the test showing extremely high sensitivity and specificity.
SwabSeq uses sample-specific molecular barcodes to simultaneously analyze thousands of samples for the presence or absence of SARS-CoV-2, the virus that causes COVID-19. SwabSeq was granted FDA Emergency Use Authorization in October and is currently deployed at UCLA in a high-complexity CLIA laboratory, which has performed over 150,000 tests since December 2020. SwabSeq is a flexible protocol and can rapidly scale up testing for novel pathogens, including COVID-19 and
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Postmenopausal Women At Greater Risk For Subsequent Bone Fractures by Karishma Abhishek on May 5, 2021 at 11:57 PM
Fractures in the arm, wrist, leg, and other parts of the body should also set off alarm bells for increasing the risk for subsequent bone breaks in the current guidelines for managing osteoporosis apart from specifically calling out hip or spine fractures as per the University Of California - Los Angeles Health Sciences (UCLA) -led study, published in the peer-reviewed journal EClinicalMedicine. A fracture, no matter the location, indicates a general tendency to break a bone in the future at a different location. Current clinical guidelines have only been emphasizing hip and spine fractures, but our findings challenge that viewpoint. By not paying attention to which types of fractures increase the risk of future fractures, we are missing the opportunity to identify people at increased risk of future fracture and counsel them regar
Why Does COVID-19 Boost Stroke Risk?
A UCLA-led study using 3D-printed “blood vessels” aims to identify a possible link between coronavirus and stroke. The study was published in
In the study, UCLA researchers used a 3D-printed silicone model of blood vessels in the brain to mimic the forces generated by blood pushing through an artery that is abnormally narrowed, a condition called intracranial atherosclerosis. They showed that as those forces act on the cells lining the artery, and increase the production of a molecule called angiotensin-converting enzyme 2, or ACE2, which the coronavirus uses to enter cells on the surface of blood vessels.