(a) High-resolution 3D MRI brain vascular map using SAIO. Various blood vessels in the rat brain can be visualized. In addition to clinically important brain vessels including anterior cerebral artery, middle cerebral artery, posterior cerebral artery, fine vessel structures as thin as ~ 100 microns in diameter can be clearly visualized. (b) 3D MRI brain vascular map using Dotarem (gadolinium-based contrast agent). Resolution is low and microvessels are not visible. (c) For 3D reconstruction, multiple slices of MRI images of the rat heart were obtained after injection of SAIO. Rat coronary arteries (180 microns) which are 10 times thinner than human coronary arteries were successfully visualized. Coronary arteries supply blood to the heart muscle and the blockage or narrowing of such arteries causes myocardial infarction or angina, but visualizing these arteries was impossible due to the limited resolution of current MRI contrast agents. Image courtesy of Institute for Basic Science
Radiology and Radiation Oncology | Imaging Technology News itnonline.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from itnonline.com Daily Mail and Mail on Sunday newspapers.
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Ludwig Institute for Cancer Research mourns death of former Board Member and Trustee Sir Derek Roberts
FEBRUARY 26, 2021, NEW YORK – It is with great sadness that we report the death of former Ludwig Board Member and Trustee, Sir Derek Roberts, who passed away on February 17th at the age of 88 due to complications from COVID-19. Sir Derek served on Ludwig’s Board for nearly 14 years before stepping down in 2012.
An engineer who twice served as provost of University College London, Sir Derek oversaw several successful projects and the university’s expansion during his tenure, including its merger with the Institute of Child Health. He was an early pioneer of silicon-based integrated circuit technology, now ubiquitous in electronic devices from PCs to satellites. His professional life was spent primarily in industrial scientific research, first at Plessy-one of Britain’s largest electronics manufacturers-developing complex integrated circuits, and subsequen
Cancer immunotherapy can disable suppressive immune cells to aid tumor destruction news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.
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IMAGE: Taha Merghoub and Jedd Wolchok of the Ludwig Center at Memorial Sloan Kettering Cancer Center (MSK) and former postdoc Roberta Zappasodi view more
Credit: Ludwig Cancer Research
FEBRUARY 15, 2021, NEW YORK - A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors. The tumors in question are relatively less reliant on burning sugar through a biochemical process known as glycolysis.
Researchers led by Taha Merghoub and Jedd Wolchok of the Ludwig Center at Memorial Sloan Kettering Cancer Center (MSK) and former postdoc Roberta Zappasodi now at Weill Cornell Medicine have discovered that in a mouse model of glycolysis-deficient tumors, CTLA-4 blockade does much more than stimulate cancer-targeting T cells of the immune system. In such tumors, anti-CTLA-4 therapy also destabilizes and reprograms regulatory T