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Innovative breakthrough promises to diagnose DNA rearrangement mutations
Doctors are increasingly using genetic signatures to diagnose diseases and determine the best course of care, but using DNA sequencing and other techniques to detect genomic rearrangements remains costly or limited in capabilities.
However, an innovative breakthrough developed by researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Department of Physics promises to diagnose DNA rearrangement mutations at a fraction of the cost with improved accuracy.
Led by VCU physicist Jason Reed, Ph.D., the team developed a technique that combines a process called digital polymerase chain reaction (dPCR) with high-speed atomic force microscopy (HSAFM) to create an image with such nanoscale resolution that users can measure differences in the lengths of genes in a DNA sequence. These variations in gene length, known as polymorphisms, can be key to accurately diagnosing many forms of cancer and ne
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IMAGE: From left, postdoctoral scholar Andrey Mikheykin, Ph.D., Jason Reed, Ph.D., and postdoctoral fellow Sean Koebley, Ph.D., worked together on the study. view more
Credit: John Wallace, VCU Massey Cancer Center
Doctors are increasingly using genetic signatures to diagnose diseases and determine the best course of care, but using DNA sequencing and other techniques to detect genomic rearrangements remains costly or limited in capabilities. However, an innovative breakthrough developed by researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Department of Physics promises to diagnose DNA rearrangement mutations at a fraction of the cost with improved accuracy.
VCU technology can turn DNA sequencing on its head for diagnosing certain DNA mutations
News Highlights: VCU technology can turn DNA sequencing on its head for diagnosing certain DNA mutations
PICTURE: From left to right, postdoctoral researcher Andrey Mikheykin, Ph.D., Jason Reed, Ph.D., and postdoctoral fellow Sean Koebley, Ph.D., collaborated on the study. view more
Credit: John Wallace, VCU Massey Cancer Center
Physicians are increasingly using genetic signatures to diagnose diseases and determine the best care, but the use of DNA sequencing and other techniques to detect genomic rearrangements remains expensive or limited in scope. However, an innovative breakthrough developed by researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Department of Physics promises to diagnose DNA rearrangement mutations at a fraction of the cost with improved accuracy.