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Large clinical trial to study repurposed drugs to treat COVID-19 symptoms

Using an ACTIV master protocol, the trial will focus on potential interventions for mild-to-moderate illness. The National Institutes of Health will fund a large, randomized, placebo‑controlled Phase 3 clinical trial to test several existing prescription and over-the-counter medications for people to self-administer to treat symptoms of COVID-19. Part of the Accelerating COVID‑19 Therapeutic Interventions and Vaccines (ACTIV) public–private partnership, the ACTIV-6 trial aims to provide evidence-based treatment options for the majority of adult patients with COVID-19 who have mild-to-moderate symptoms and are not sick enough to be hospitalized. NIH will provide an initial investment of $155 million in funding for the trial.

United statesNorth carolinaVanderbilt universityFranciss collinsJoni rutterNational centerVanderbilt institute for clinicalVanderbilt university medical centerUs department of healthHuman servicesNational institutes of healthDrug administrationDuke clinical research instituteTranslational sciencesDuke vanderbilt trial innovation centerNational patient

Vanderbilt University Medical Center to help study repurposing drugs for COVID-19

Vanderbilt University Medical Center to help study repurposing drugs for COVID-19
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Christopher lindsellResearch methods programVanderbilt institute for clinicalVanderbilt university medical centerDrug administrationDuke clinical research instituteTranslational researchVanderbilt instituteவாண்டர்பில்ட் நிறுவனம் க்கு மருத்துவவாண்டர்பில்ட் பல்கலைக்கழகம் மருத்துவ மையம்டியூக் மருத்துவ ஆராய்ச்சி நிறுவனம்மொழிபெயர்ப்பு ஆராய்ச்சிவாண்டர்பில்ட் நிறுவனம்

Large clinical trial to study repurposed drugs to treat COVID-19 symptoms

Large clinical trial to study repurposed drugs to treat COVID-19 symptoms
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United statesNorth carolinaVanderbilt universityFranciss collinsJoni rutterNational centerVanderbilt institute for clinicalVanderbilt university medical centerNational institutes of healthDrug administrationDuke clinical research instituteTranslational sciencesDuke vanderbilt trial innovation centerClinical research networkNational patientOutcomes research institute

Research: Better understanding of fundamental cell behavior can improve drug development

Date Time Research: Better understanding of fundamental cell behavior can improve drug development Pioneering research from Vanderbilt scientists shows that cells respond differently to acute stress than to gradual stress. The findings establish an entirely new way to look at cell-to-cell communication, or signaling, and may fundamentally change how biomedical researchers study cells. Alexander Thiemicke Gregor Neuert Research led by Alexander Thiemicke, former graduate student in chemical and physical biology, and Gregor Neuert, assistant professor of molecular physiology and biophysics, was published in the journal Science Advances on Feb. 19. Their study sought to clarify how cells behave in environments where stress is changed gradually, as opposed to conditions that produce rapid change.

United statesHossein jashnsazAlexander thiemicke gregor neuertAmanda johnsonGregor neuertAlexander thiemickeAmerican heart associationVanderbilt institute for clinicalMunsky groupColorado state universityProceedings of the national academy sciencesComputing centerTranslational researchNational instituteScience advancesFaculty fellow

Vanderbilt, Zambia Researchers Find Delirium in Hospitalized Patients Linked to Mortality, Disability in Sub-Saharan Africa

Vanderbilt University Medical Center Wesley Ely, MD, MPH, co-director of the Critical Illness, Brain Dysfunction, and Survivorship Center at VUMC and senior author. Newswise Delirium, a form of acute brain dysfunction, is widespread in critically ill patients in lower resourced hospitals, and the duration of delirium predicted both mortality and disability at six months after discharge, according to a study published in PLOS ONE. Working with partners in Zambia, Vanderbilt University Medical Center researchers evaluated 711 hospitalized critically ill patients; delirium occurred in 48.5%. The findings shed light on the impact of delirium on a patient’s recovery and even whether a patient is likely to live or die.

Zambia generalUniversity of zambiaJustin banerdtDouglas heimburgerWesley elyYale school of medicineVanderbilt institute for clinicalVanderbilt university medical centerNational institutes of healthVanderbilt institute for global healthVanderbilt university school of medicineVanderbilt medical scholars programFogarty international centerVanderbilt emory cornell duke consortium for global health fellowsTranslational researchSurvivorship center