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Galway scientist among researchers on US Army-developed vaccine

Accelerated cellular aging in depressed individuals associated with increased mortality risk

Accelerated cellular aging in depressed individuals associated with increased mortality risk Cells from healthy individuals with major depressive disorder were found to have higher than expected rates of methylation at specific sites on their DNA, when compared to cells from healthy individuals without MDD, according to a study by a multidisciplinary team of Walter Reed Army Institute of Research and University of California San Francisco scientists, in collaboration with others. Methylation is a process by which DNA is chemically modified at specific sites, resulting in changes in the expression of certain genes. Methylation of particular sets of genes, called DNA methylation clocks, typically change in predictable ways as people age, but the rate of these changes varies between people. Methylation patterns in individuals with MDD suggested that their DNA methylation cellular age was, on average, accelerated relative to matched healthy controls.

Army scientists hope their COVID-19 vaccine will be a universal booster shot

. WASHINGTON (Tribune News Service) Army scientists are testing whether their new COVID-19 vaccine candidate, which entered human trials this week, can serve as a universal booster shot for all other available coronavirus vaccines. Nearly 20% of Americans have already been fully vaccinated against COVID-19 using one of three authorized vaccines. But with public health experts and government officials anticipating the need for booster shots down the line, scientists at the Walter Reed Army Institute of Research are examining whether their vaccine candidate can “mix and match” with the others to enhance and prolong protection. The Walter Reed vaccine called SpFN may boost the duration and breadth of immune responses in combination with other vaccines, which are made using different technologies, Dr. Kayvon Modjarrad, director of Walter Reed’s Emerging Infectious Diseases Branch, said in an interview with McClatchy on Thursday.

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