Immune cell implicated in development of lung disease following viral infection
Findings could help explain how asthma, COPD, severe COVID-19 are triggered
Holtzman Lab
A new study from Washington University School of Medicine in St. Louis implicates a type of immune cell called a dendritic cell in the development of chronic lung diseases that can follow after a respiratory viral infection. Shown is a stained section of mouse lung. Epithelial cells, which line the airway, are red. Dendritic cells are green. Any cell nuclei are blue.
Newswise Scientists at Washington University School of Medicine in St. Louis have implicated a type of immune cell in the development of chronic lung disease that sometimes is triggered following a respiratory viral infection. The evidence suggests that activation of this immune cell a type of guardian cell called a dendritic cell serves as an early switch that, when activated, sets in motion a chain of events that drives progressive lung d
Scientists have implicated a type of immune cell in the development of chronic lung disease that is sometimes triggered following a respiratory viral infection. The evidence suggests that activation of this immune cell serves as an early switch that, when activated, sets in motion a chain of events that drives progressive lung diseases.<br />
New study may lead to therapeutic strategies for chronic lung disease
Scientists at Washington University School of Medicine in St. Louis have implicated a type of immune cell in the development of chronic lung disease that sometimes is triggered following a respiratory viral infection.
The evidence suggests that activation of this immune cell a type of guardian cell called a dendritic cell serves as an early switch that, when activated, sets in motion a chain of events that drives progressive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD).
The new study, published in The
Journal of Immunology, opens the door to potential preventive or therapeutic strategies for chronic lung disease. More immediately, measuring the levels of these dendritic cells in clinical samples from patients hospitalized with a viral infection, such as influenza or COVID-19, could help doctors identify which patients are at high risk of respiratory failure and death.
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