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Non-calcium-based phosphate binders weren t any better at reducing cardiovascular events than calcium-based binders in dialysis patients, the LANDMARK trial determined.
In the open-label randomized trial of over 2,300 Japanese patients on hemodialysis, there were no significant differences in composite cardiovascular events between the lanthanum carbonate group versus the calcium carbonate group (HR 1.11, 95% CI 0.88-1.41,
P=0.37), reported Hiroaki Ogata, MD, of Showa University Northern Yokohama Hospital in Kanagawa, Japan, and colleagues.
These heart events included cardiovascular death, nonfatal myocardial infarction or stroke, unstable angina, transient ischemic attack, or hospitalization for heart failure or ventricular arrhythmia, the group explained in
During the median 3.16-year follow-up period, 147 of 1,063 dialysis patients using lanthanum carbonate experienced cardiovascular events compared with 134 of 1,072 patients in the calcium carbonate gro