this is cnn breaking news. welcome to the lead. i m jake tapper. we start this hour with breaking news. israel says a new group of hostages has been freed. it includes an american citizen. we saw the red cross convoy leaving gaza and entering egypt. the idf says this group consists of 14 people headed right now to meet up with israeli forces. 48-year-old leat bamin is now the second american released since the start of this pause in the violence between israel and hamas. after we saw 4-year-old abigail edan released earlier this week. let s get right to cnn s oren lieberman who is in save, and cnn s jeremy diamond who is in israel. jeremy, we re learning more about this batch of hostages, including this american dual citizen. tell us more. reporter: that s right. among these ten israeli hostages who have been freed, there are four thai nationals who have also been freed. i want to read you the names that we are getting, including the woman you mentioned, the 48-year-old
that breaking news out of the capital and the attempted carjacking of a secret service vehicle happening last night in georgetown. agents protecting the president s granddaughter opened fire thwarting the carjacking. details coming right up. striking back with deadly force, the u.s. launching new air strikes of proxies in syria. asme owe dana perino. bill is off today. hi, mike. mike: i m mike emanuel. america s newsroom. sources say one of the american strikes killed at least half a dozen iranian-backed fighter after a flurry of attacks against american troops throughout the region. dana: coinciding with israel s war on hamas. they continue to hunt the terrorists in gaza and fending off strikes from lebanon where the iranian-back terrorists of hezbollah have become increasingly active. mike: general jack keane analysis but alex hogan is live from northern israel where fighting is on the rise. major escalation here in the northern part of israel. the sound of artill
of coastal areas of los lagos region around puerto montt. in his christmas sermon, the archbishop of canterbury says the power of god can chase away the fear of terror . now on bbc news the click team celebrates christmas and looks back at the best bits from 2016. this week, a click christmas with digital jumpers, hatched technology and tie fighters. hello and welcome to the annual click get together. cue christmas cheer! and enough. we have everyone here, jen, steve, nick, laura, mark and kate russell. hello. i have sought out a little christmas gift for you. thank you very much. it s an egg. it is an egg. right. inside it is a hatchimal, it s the latest robotic, interactive toy. it s got loads of sensors and it s for ages five and up and your child basically has to nurture the egg in order to hatch it and then it breaks its way out of the egg and then you teach it games. you care for it, basically. you have to feed it. you re going to be a daddy. thank you very much. i s
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by cytoplasmic deposition of the nuclear TAR-binding protein 43 (TDP-43). Although cytoplasmic re-localization of TDP-43 is a key event in the pathogenesis of ALS/FTD, the underlying mechanisms remain unknown. Here, we identified a non-canonical interaction between 14-3-3θ and TDP-43, which regulates nuclear-cytoplasmic shuttling. Neuronal 14-3-3θ levels were increased in sporadic ALS and FTD with TDP-43 pathology. Pathogenic TDP-43 showed increased interaction with 14-3-3θ, resulting in cytoplasmic accumulation, insolubility, phosphorylation, and fragmentation of TDP-43, resembling pathological changes in disease. Harnessing this increased affinity of 14-3-3θ for pathogenic TDP-43, we devised a gene therapy vector targeting TDP-43 pathology, which mitigated functional deficits and neurodegeneration in different ALS/FTD mouse models expressing mutant or non-mutant TDP-43, including when already