1Department of Orthopeadics, The Affiliated Linfen Hospital of Shanxi Medical University, Linfen, Shanxi Province, People’s Republic of China;
2Department of Orthopeadics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province, People’s Republic of China;
3Department of Orthopeadics, The Affiliated Shunde Hospital of Jinan University, Foshan, Guangdong Province, People’s Republic of China These authors contributed equally to this work
Correspondence: Xinghua Song
Department of Orthopeadics, The Affiliated Shunde Hospital of Jinan University, Foshan, 528303, People’s Republic of China
Zhen Wang
Department of Orthopeadics, The Affiliated Linfen Hospital of Shanxi Medical University, Linfen, 041000, People’s Republic of China
6 MiRNAs are critical components of competing endogenous RNA network in cells.
7 Via binding to complementary sites on mRNA 3ʹUTR, miRNAs promote mRNA degradation or inhibit mRNA translation to repress gene expression.
8 Dysregulation of miRNAs results in abnormal expression of target genes and is associated with cancer development.
9 Hundreds of cancer-associated miRNAs have been reported in colorectal cancer.
10,11 For example, miR-193a-3p, which is downregulated in BRAF-mutated colorectal cancers, inhibits colorectal cancer cell proliferation.
12 MiR-4449 is highly expressed in serum from patients with multiple myeloma compared with samples from healthy volunteers.
13 However, the precise function of miR-4449 in colorectal cancer is not known.
D) Immunohistochemical staining of COX-2 and iNOS inflammatory factors in liver tissue. (
E and
F) Inflammatory cell expression area
%Data are presented as the mean±SD (n=10). As compared with the normal group,
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