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Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Research unveils the significance of uridine as a metabolic fuel in pancreatic ductal adenocarcinoma (PDA) cells under glucose-deprived conditions. Uridine utilization, mediated by uridine phosphorylase 1 (UPP1), supports redox balance, survival, and proliferation in PDA, highlighting its potential as a novel therapeutic target in the treatment of this resistant cancer.
Kateryna Kon Tarun Sai Tarun Sai Lomtemay Pancreatic Cancer Amino Acid Cell Line

Caffeine connection: Pre-teen caffeine consumption linked to early nicotine use

Research explores the relationship between caffeine use and nicotine onset among early adolescents, shedding light on a potential contributing factor to youth nicotine initiation. It emphasizes the importance of understanding the influence of caffeine in preventing early nicotine use.
West Virginia United States Liji Thomas Young Mountaineer Health Study Cohort Young Mountaineer Health Study Image Credit

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MyJournals.org - Science - 'Pharmaceuticals, Vol. 16, Pages 732: Nonselective and A2a-Selective Inhibition of Adenosine Receptors Modulates Renal Perfusion and Excretion Depending on the Duration of Streptozotocin-Induced Diabetes in Rats' (Pharmaceuticals)

MyJournals.org - Science - Pharmaceuticals, Vol. 16, Pages 732: Nonselective and A2a-Selective Inhibition of Adenosine Receptors Modulates Renal Perfusion and Excretion Depending on the Duration of Streptozotocin-Induced Diabetes in Rats (Pharmaceuticals)
2a Selective Treptozotocin Induced

Researchers identify the mSWI/SNF chromatin remodeling complex as a host-directed drug target for SARS-CoV-2 infection

Researchers showed that mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) chromatin remodeling complexes represent a potential class of host-directed broad-acting SARS-CoV-2 therapeutic targets.
Kateryna Kon Shutterstock Cancer Research Industry Cancer Research Nature Genetics Sucrose Non Fermentable Matrix Associated

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