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Merck & Co., Inc.: Merck Receives Positive EU CHMP Opinion for KEYTRUDA (pembrolizumab) as Adjuvant Treatment for Adult and Adolescent (=12 Years of Age) Patients With Stage IIB or IIC Melanoma Following Complete Resection

Opinion granted based on positive results from the Phase 3 KEYNOTE-716 trial If approved, KEYTRUDA would be the first anti-PD-1 immunotherapy treatment option for patients 12 years and older in
United States Scot Ebbinghaus Peter Dannenbaum Damini Chokshi Melissa Moody Merck Research Laboratories

Frontiers | Vaccination With a Gamma Irradiation-Inactivated African Swine Fever Virus Is Safe But Does Not Protect Against a Challenge

African swine fever (ASF) is among the most devastating viral diseases of pigs and wild boar worldwide. In recent years, the disease has spread alarmingly. Despite intensive research activities, a commercialized vaccine is still not available, and efficacious live attenuated vaccine candidates raise safety concerns. From a safety perspective, inactivated preparations would be most favourable. However, both historical and more recent trials with chemical inactivation did not show an appreciable p...
Nordrhein Westfalen United States Bad Homburg San Diego La Garenne Colombes France General

F. Hoffmann-La Roche Ltd: CHMP recommends EU approval of Roche's Tecentriq as adjuvant treatment for a subset of people with early-stage non-small cell lung cancer

In the Phase III IMpower010 trial, adjuvant Tecentriq reduced the risk of disease recurrence or death by 57% in people with PD-L1 high resectable Stage II-III NSCLC compared with best supportive careMore
United Kingdom United States Nathalie Meetz Levi Garraway Karl Mahler Europe Lu

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Bristol Myers Squibb Receives European Commission Approval for Opdivo (nivolumab) as Adjuvant Treatment for Patients with Radically Resected, High-Risk Muscle-Invasive Urothelial Carcinoma with Tumor Cell PD-L1 Expression =1%

Approval based on Phase 3 CheckMate -274 trial results showing that adjuvant treatment with Opdivo significantly reduced patients' risk of disease recurrence or death compared to placebo Opdivo
United States South Korea Dana Walker Fred Witjes Opdivo Monotherapy Bristol Myers Squibb

Merck & Co., Inc.: European Commission Approves Merck's KEYTRUDA (pembrolizumab) as Adjuvant Therapy for Certain Patients With Renal Cell Carcinoma (RCC) Following Surgery

KEYTRUDA Is Now Approved as Monotherapy for Adults With RCC at Increased Risk of Recurrence Following Nephrectomy, or Following Nephrectomy and Resection of Metastatic Lesions KEYTRUDA Is the First
United States Scot Ebbinghaus Peter Dannenbaum John Infanti Melissa Moody Damini Chokshi

"BRAF mutation testing for patients diagnosed with stage III or stage I" by Richard A. Scolyer, Victoria Atkinson et al.

Targeted therapy (BRAF inhibitor plus MEK inhibitor) is now among the possible treatment options for patients with BRAF mutation-positive stage III or stage IV melanoma. This makes prompt BRAF mutation testing an important step in the management of patients diagnosed with stage III or IV melanoma; one that can help better ensure that the optimal choice of systemic treatment is initiated with minimal delay. This article offers guidance about when and how BRAF mutation testing should be conducted ...
United States American Joint Committee On Cancer Union For International Cancer Control American Joint Committee International Cancer Control Raf Mutation Testing
Source: uow.edu.au

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