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<p>In the development of Parkinson&rsquo;s disease (PD), the changes that will lead to neurodegeneration take place in the brain long before patients show any symptoms. But without a test that can detect these changes, it&rsquo;s difficult to intervene early to more effectively slow disease progression.&nbsp;</p> <p>Researchers from the&nbsp;<a href="http://brighamandwomens.org/">Brigham and Women&rsquo;s Hospital</a>, a founding member of&nbsp;<a href="http://massgeneralbrigham.org/">Mass General Brigham</a>,&nbsp;<u>and</u>&nbsp;<a href="https://wyss.harvard.edu/">Wyss Institute for Biologically Inspired Engineering at Harvard University</a>&nbsp;have&nbsp;developed a molecular assay platform that they successfully applied to patient samples to detect and quantify single&nbsp;⍺-synuclein fibrils, the pathogenic aggregates of&nbsp;⍺-synuc

United statesBoston universitySpaulding rehabilitation hospitalUniversity of massachusetts medical schoolMassachusetts institute of technologyTufts universityFaulkner hospitalDavid weitzRobert breck brighamElla borbergBrendan deveneyVikram khuranaAnastasia kuzkinaRohan thakurDanqi chenAlain ndayisaba