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The STOP-CAD study signaled a short course of an antithrombotic regimen might lower ischemic stroke risk in some patients without significantly increasing major bleeding.
New observational data suggested direct oral anticoagulants may be the optimal antithrombotic regime after transcatheter mitral valve replacement; randomized trials were needed.
Treatment with warfarin early after bioprosthetic surgical aortic valve replacement is associated with lower mortality and thromboembolism risk but increased major bleeding events.