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Young People May Have More Side Effects From the COVID Vaccine - Doctors Explain Why PopSugar 3/5/2021 Samantha Brodsky © Getty / LifestyleVisuals Young People May Have More Side Effects From the COVID Vaccine - Doctors Explain Why Not everyone who gets vaccinated for COVID-19 has side effects. And, when people do have short-term side effects such as injection-site reactions, fatigue, fever, headache, and muscle aches and pain, they tend to happen more frequently after the second dose of the mRNA vaccines - from Pfizer-BioNTech and Moderna - currently approved for emergency use by the FDA as opposed to the first. Note: the single-dose Johnson & Johnson vaccine was approved for emergency use in the United States on Feb. 27, and mild to moderate side effects reported in clinical trials were similar, lasting on average one to two days.

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