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Nationwide dispensing of cardioprotective medications during the first year following acute coronary syndrome (ANZACS-QI 56) Open Access PDF Download Unless contraindicated, the current guidelines for secondary prevention following acute coronary syndrome (ACS) recommend a statin for all patients. Patients should also receive combination antithrombotic therapy—usually a combination of aspirin and a PY212 inhibitor antiplatelet agent. But, for patients with atrial fibrillation, an oral antico...

9). We report trends in management and outcomes of melioidosis over 10 years at a nongovernmental pediatric hospital in northern Cambodia. The Study This study was approved by the hospital institutional review board (AHC IRB 979-14; 1044-15) and the Oxford Tropical Medicine Research Ethics Committee (OxTREC 550-14). Data on all culture-confirmed case-patients who had B. pseudomallei infection during January 1, 2009–December 31, 2018, were collected retrospectively (2009–2013) and prospecti...

Impact of burnout on empathy Open Access PDF Download Burnout—a syndrome that is characterised by emotional exhaustion, depersonalisation and low sense of personal accomplishment—has been associated with a higher frequency of medical errors, lapses in professionalism, impeded learning, problematic alcohol use and suicidal ideation. Burnout is important because it can damage doctors and impair patient care. Burnout is defined as “a state of physical, emotional and mental exhaustion that r...

Children on the move: the tale of a surprising spillover in humanitarian cash transfers to refugees Imagine the following scenario: you have a population consisting of two groups, who are, on average, equally poor at baseline. You randomly pick one group to receive sizeable cash transfers: what would happen to inequality within this population? It should increase, mainly because you increased between-group inequality, which was negligible at the start (assume away, if you wish, within-group ine...

We thank 2 anonymous reviewers for their helpful comments on the manuscript. M.V. was funded by the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement no. 852957). J.Y. was supported by a Collaborative Awards in Science and Engineering studentship funded by the Natural Environment Research Council, Swindon, UK. References Dennis  D, Hayes  E. Epidemiology of Lyme borreliosis. In: Gray J, Kahl O, Lane R, Stanek G, editors. Ly...

Abstract We report 3 cases of Puumala virus infection in a family in Switzerland in January 2019. Clinical manifestations of the infection ranged from mild influenza-like illness to fatal disease. This cluster illustrates the wide range of clinical manifestations of Old World hantavirus infections and the challenge of diagnosing travel-related hemorrhagic fevers. Puumala orthohantavirus (PUUV), a species of the genus Orthohantavirus within the Hantaviridae family, is an enveloped single-stran...

Abstract Since May 2019, the Central African Republic has experienced a poliomyelitis outbreak caused by type 2 vaccine-derived polioviruses (VDPV-2s). The outbreak affected Bangui, the capital city, and 10 districts across the country. The outbreak resulted from several independent emergence events of VDPV-2s featuring recombinant genomes with complex mosaic genomes. The low number of mutations ( 20) in the viral capsid protein 1–encoding region compared with the vaccine strain suggests that...

Plasmodium falciparum populations from Sudan, South Sudan, Nigeria, and Eritrea (A), and pfhrp2 and ... We amplified and scored 7 microsatellite loci for each sample from Sudan, South Sudan, and Nigeria (n = 86), finding 88 unique haplotypes. Two samples shared a haplotype, and we observed 2 instances of multiple haplotype infection. All 7 microsatellite markers were found to be polymorphic. We found a mean of 11 alleles per locus, a range from 6 (microsatellite markers TA109 and 2490) to 16 (...

Norovirus GII.4 viruses have caused most gastroenteric infections for >2 decades, and new variants have emerged every 2–4 years since 2002 ( 7). Six pandemic GII.4 variants have been named after the place of first reported sequence and year of predominance: US 95–96, Farmington Hills 2002, Hunter 2004, Den Haag 2006, New Orleans 2009, and Sydney 2012. Several norovirus vaccine candidates are in preclinical studies and clinical trials ( 8); however, it is currently unclear if these vaccine f...

3), so vector roles of both species should not be overlooked. TBRF courses with febrile episodes and should be considered as a differential diagnosis within the spectrum of diseases that cause an undifferentiated febrile syndrome (UFS) ( 6). Although specific data are vague for the states where tick collections were performed in this study, UFS is common in Brazil; mosquitoborne viruses and malaria are the main etiologic agents ( 8). Nevertheless, febrile illnesses still remain underdiagnosed i...