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31 March 2021 The liver is one of the organs most susceptible to drug toxicity and drug induced liver injury (DILI). DILI is a major cause of drug attrition, with more than 750 FDA approved drugs known to have a degree of DILI risk. There are a number of strategies to de-risk DILI in drug discovery and, in recent years, focus has turned to human in vitro 3D liver models to better predict DILI in early and pre-clinical development. These models culture primary human liver cells, often in co...

15 March 2021 In this application note, The Jackson Laboratory demonstrate how the cord blood CD34+ hematopoietic stem cell (HSC) humanized NSG™-IL15 mouse enables in vivo efficacy research for compounds targeting human natural killer (NK) cell activity including antibody-dependent cellular cytotoxicity (ADCC). Download 10,000+

SERS is a potentially useful tool for identifying pesticide residues on the surface of fruits for food quality and safety control.

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5 March 2021 The identification and discrimination of apoptotic, necrotic and viable cells is important in a variety of different biological research fields.  In this application note, Tecan demonstrate the potential of the Spark ® Cyto for use in apoptosis research through performance comparison with a benchmark high content imager.    Download 10,000+

Temperature control units with hydrocarbons

4 March 2021 In this application note, Tecan demonstrates how the Fluent Mix and Pierce Workstation provides automation for sample distribution without the need for tube decapping, therefore eliminating tedious manual work and the risk of technical or human errors. Download 10,000+

Power is not the same as efficiency

4 March 2021 Reliable and accurate cell counts are crucial for many different purposes such as the maintenance of cell cultures in biological research or in-process controls in industrial bioprocessing. When considering currently available cell counting options, many users ask which cell counting method is better: manual counting or using automated cell counters.  In this application note, anvajo GmbH demonstrate that the fluidlab R-300 can be successfully employed for automated cell counting ...

Mar 04 2021 Read 513 Times A wide variety of cannabis derived products are now available for purchase, although the legality of these products varies from country to country. Within Europe, products containing more than 0.2% tetrahydrocannabinol (THC) are banned, however cannabidiol (CBD) containing products are legal. This note compares the FTIR spectra obtained from two such legal products. Method Two commercially available Cannabidiol (CBD) food supplements were obtained. One was specified a...