Page 31 - Application Note News Today

Raman Spectroscopy is a non-destructive chemical analysis technique which provides detailed information

In this application note, PCR Biosystems presents air-dryable qPCR and RT-qPCR reagents as a cost-effective solution for assay development and diagnostics. These reagents enable fast drying in a standard laboratory oven, allowing organizations to create high-performance dried assays in-house without significant costs or infrastructure. Air-dried assays offer advantages such as reduced susceptibility to moisture and eliminate the need for strict humidity control during manufacturing. The reagents

Bruker Nano utilizes hardness mapping to characterize the two phases of a DP (dual-phase) steel sample

Application of in-situ SEM nanoindentation with the Hysitron PI 88 SEM PicoIndenter of a high-entropy alloy

Syft Technologies provides information on how its mass spectrometry instruments can increase productivity

It takes a while for audio-related technologies to mature. Tubed amplifiers were invented by Lee de Forest in the nineteen-teens, but while there are still some adherents of early high-distortion triode designs, the age of mainstream high-fidelity amplification dawned with higher-power/lower-distortion amplifiers developed by Williamson and McIntosh followed by the Ultralinear take on the Williamson concept. That was 30+ years down the technology-evolution timeline after de Forest.

In this application note, Tecan presents a method for diagnosing Cushings syndrome efficiently and accurately. The approach involves simultaneous the measurement of cortisol and dexamethasone levels using LC-MS/MS, which reduces false positives in dexamethasone suppression test (DSTs). The described LC-MS/MS method enables the tracking of multiple analytes, including cortisol, cortisone, and dexamethasone, in serum or plasma. Implementing this analytical approach offers clinical laboratories a

In this application note, Bio-Rad addresses the challenges of residual host cell DNA contamination in cell and gene therapy products. Residual host cell DNA contamination poses risks such as dangerous immune responses and oncogenic effects, compromising the safety and therapeutic benefits of the products. Regulatory standards require limiting residual host cell DNA to safe levels. Traditional methods like qPCR and BioAnalyzer have limitations in quantification and sizing. Droplet Dig

In this application note, Zymo Research emphasizes the significant impact of plasmid DNA quality on transfection success. Four key points are highlighted: The DNA should be predominantly supercoiled and free of genomic DNA and RNA, as circular plasmids are more efficiently taken up by cells, while contamination confuses quantification. The DNA should be highly concentrated and devoid of phenol, salts, and protein to prevent dilution of transfection reagents,

In this ebook, Bio-Rad explores the advancements of RNA as a therapeutic molecule, offering hope for previously undruggable targets. Challenges in RNA therapeutics, such as minimizing immune reactions and optimizing delivery, must be addressed for full potential. Robust analytical tools, including droplet digital polymerase chain reaction technology (ddPCR), play a crucial role in successful development. ddPCR offers quantification, sensitivity, and specificity, supporting safe and effectiv