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Nitrosamines are carcinogenic, even at trace levels. As a result, the FDA has issued guidance regarding monitoring nitrosamine impurities in drugs for human consumption [1].

Synthetic replicas of endogenous steroids are both chemically and pharmacologically indistinguishable from their natural counterparts. By examining isotopes within these steroids, distinct isotope fingerprints emerge in urinary samples, creating a reliable discrimination framework. Explore the concept of Isotope Fingerprints and their application in doping control investigations. Discover how these fingerprints play a crucial role in distinguishing between naturally produced (endogenous) and ext

Stable isotope labelling is a powerful technique which allows tracking down drug metabolism. This application brief reports how isotope fingerprints have been effectively investigated to detect labeled metabolites of drug of abuse by using gas chromatography isotope ratio mass spectrometry (IRMS).

Breath samples, specifically volatile organic compounds (VOCs), have been explored for decades to identify health and disease changes. Advances in genomics and metabolomics, along with high-throughput analysis, have expanded this field. Breath testing, as a non-invasive tool, facilitates early disease detection and personalized treatment through precision medicine. The Breath Biopsy™ method, using Orbitrap™ technology, is a breakthrough for pain-free and reliable testing, providing insights ...

Analyzing trace elements in biological samples is crucial for clinical research, offering insights into cellular functions. Essential elements like zinc, copper, selenium, and others play vital roles in biochemical reactions. Increased exposure to toxic heavy metals poses health risks. This study reports an analytical method for quantifying 28 trace elements in human plasma and serum, utilizing the ClinMass Complete Kit and Thermo Scientific™ iCAP™ TQ ICP-MS.

Latest News from the Electronics Industry - Electropages

Cell morphology is one of the strongest indicators of cell health. However, there is no current consensus on exactly how cell morphology should be quantified. Incucyte ® Live-Cell Analysis Systems enable cells to be visualized from within an incubator over long periods of time. This application note dives into the various applications of morphometry in live-cell analysis.

This application note demonstrates the benefit of incorporating of HRIM into traditional LC-MS workflows for reproducible high-throughput targeted PTM analysis for biopharmaceutical characterization.

With a shortage of lab personnel and rising costs, hematology labs are under pressure to boost efficiency. Lab digitalization and automation are key. While digital peripheral blood smear (PBS) analysis has gained popularity, its limited field of view necessitates manual examination for abnormal samples. The Scopio Labs X100 Full-Field Peripheral Blood Smear™ platform eliminates manual microscopy, offering a full-field view and enabling remote PBS review for improved workflow efficiency. This a...

Protein purification at low temperatures is crucial for preserving protein integrity and preventing proteolytic degradation, as well as managing protein aggregation tendencies. This application note offers general principles for successful protein purification in cold environments, with ÄKTA™ systems, chromatography resins, and prepacked columns typically performing well at 4°C to 8°C, similar to room temperature results.