Quantitative approach on understanding how epigenetic switches control gene expression
Credit: Nucleic Acids Research Scientists at Tokyo Institute of Technology decipher how to quantitatively assess the effects of specific epigenetic changes on the rate of transcription by developing a mathematical model. For this, they successfully generated reconstituted chromatin bearing histone modifications in vitro. Their study published in Nucleic Acids Research provides an accurate quantitative approach for understanding how site-specific changes to histone proteins impact the accessibi...
Masahiro Takinoue Kohki Okabe Takashi Umehara Biosystems Dynamics Research University Of Tokyo Takinoue Lab
Source: eurekalert.org